CardioMar 23, 2026 4 min read

Nattokinase and Blood Flow Functionality Explained

Nattokinase is an enzyme ingredient derived from fermented natto, noted for blood flow functionality. Here are enzyme-activity standardization and formulation essentials.

Nattokinase is a protein-digesting enzyme isolated from natto, a fermented soybean food. Originating in traditional Japanese cuisine, it is now a functional ingredient studied in relation to blood flow.

Nattokinase Ingredient Overview

Nattokinase is produced during soybean fermentation using Bacillus subtilis-type cultures. Its key quality metric is enzyme activity, typically standardized and labeled in FU (Fibrinolytic Units). Notably, enzyme activity (FU) — not weight (mg) — is the basis for quality comparison.

The ingredient is supplied as a powder and used in tablets and capsules.

Mechanism (Research Perspective)

Nattokinase is an enzyme with proteolytic activity studied in pathways related to blood viscosity and flow. PubMed lists multiple review articles examining its action. However, study designs and doses vary, so generalization requires caution, and in Korea related functionality is evaluated through the individually-approved ingredient process.

Simplified illustration of nattokinase enzyme isolated from fermented natto acting in pathways related to blood flow and viscosity

Dosing, Content, and Specification

As an enzyme ingredient, stability control is especially important.

Design and label content specs based on enzyme activity (FU)
Stabilize and package to prevent activity loss from heat and humidity
Manage vitamin K-related content (verify ingredient specs)

Key takeaway: Nattokinase is a blood-flow ingredient standardized by enzyme activity (FU); preserving activity and meeting approved specs are key.

OEM Formulation Considerations

Standardization: FU enzyme activity specs and activity-guaranteed CoA
Sourcing: Fermentation process stability and strain/material traceability
Regulatory check: Verify approval status for Korean claims via the Food Safety portal
Stability: Cold-chain, light-protected distribution to prevent enzyme denaturation

Blood-flow claims must stay within approved scope, and statements implying drug-like disease treatment are prohibited.

Ingredient Inquiry

For nattokinase specs by enzyme activity and approval status, browse our [ingredient catalog](/catalog) or request details via [RFQ](/rfq).

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Frequently asked questions

Should nattokinase be compared by mg or FU?

Since nattokinase is an enzyme, comparison by enzyme-activity unit FU (Fibrinolytic Unit) is more appropriate than weight (mg). Check the FU spec on the ingredient CoA.

How is nattokinase functionality approved in Korea?

Blood-flow-related functionality may be evaluated through the individually-approved ingredient process; approval status and claimable scope can be checked via the Food Safety portal.

Does the enzyme nature require storage care?

Yes. Nattokinase activity can degrade from heat and humidity, so cold-chain, light-protected distribution, stabilization, and proper packaging are recommended.

References

This content is for informational purposes only and does not guarantee the prevention or treatment of any disease. It references the following authoritative sources.